Activation Assay:Article Title: Prediction of Liver Transplant Rejection With a Biologically Relevant Gene Expression Signature
Article Snippet: .. Ingenuity Canonical Pathways -log(pvalue) -log(B-H p-value) Molecules LXR/RXR Activation 5.45 3.19 CD36,CLU,IL1R2,LYZ,MMP9 Glucocorticoid Receptor Signaling 4.57 2.8 ADRB2,CD3G,FCGR1A,IL1R2,MMP9,NFAT5,SLPI Role of NFAT in Regulation of the Immune Response 4.6 2.8 CD3G,FCGR1A,GNA12,HLA-DQB1,NFAT5 B Cell Development 4.34 2.69 HLA-DQB1,IGHM,PTPRC CD28 Signaling in T Helper Cells 4.06 2.65 CD3G,HLA-DQB1,NFAT5,PTPRC iCOS-iCOSL Signaling in T Helper Cells 4.21 2.65 CD3G,HLA-DQB1,NFAT5,PTPRC Systemic Lupus Erythematosus Signaling 4.11 2.65 CD3G,FCGR1A,IGHM,NFAT5,PTPRC Atherosclerosis Signaling 3.98 2.63 CD36,CLU,LYZ,MMP9 Dendritic Cell Maturation 3.36 2.06 CD1D,FCGR1A,HLA-DQB1,HLA-DRB4 OX40 Signaling Pathway 3.16 1.9 CD3G,HLA-DQB1,HLA-DRB4 Protein Kinase A Signaling 3 1.79 FLNA,LEF1,NFAT5,PTPN4,PTPRC T Cell Receptor Signaling 2.95 1.77 CD3G,NFAT5,PTPRC Th1 Pathway 2.78 1.64 CD3G,HLA-DQB1,HLA-DRB4 Inhibition of Angiogenesis by TSP1 2.71 1.6 CD36,MMP9 Antigen Presentation Pathway 2.59 1.56 HLA-DQB1,HLA-DRB4 Neuroinflammation Signaling Pathway 2.58 1.56 HLA-DQB1,MMP9,NFAT5,SNCA Th2 Pathway 2.64 1.56 CD3G,HLA-DQB1,HLA-DRB4 Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis 2.51 1.51 FCGR1A,IL1R2,LEF1,NFAT5 PKCθ Signaling in T Lymphocytes 2.48 1.5 CD3G,HLA-DQB1,NFAT5 Cdc42 Signaling 2.32 1.47 CD3G,HLA-DQB1,HLA-DRB4 Hematopoiesis from Pluripotent Stem Cells 2.39 1.47 CD3G,IGHM Primary Immunodeficiency Signaling 2.38 1.47 IGHM,PTPRC Systemic Lupus Erythematosus In T Cell Signaling Pathway 2.41 1.47 CD3G,GNA12,HLA-DQB1,HLA-DRB4 T Cell Exhaustion Signaling Pathway 2.33 1.47 HLA-DQB1,HLA-DRB4,NFAT5 Th1 and Th2 Activation Pathway 2.36 1.47 CD3G,HLA-DQB1,HLA-DRB4 B Cell Receptor Signaling 2.26 1.42 IGHM,NFAT5,PTPRC ILK Signaling 2.23 1.42 FLNA,LEF1,MMP9 Oxidized GTP and dGTP Detoxification 2.24 1.42 DDX6 IL-8 Signaling 2.17 1.38 DEFA1 (includes others),GNA12,MMP9 Calcium-induced T Lymphocyte Apoptosis 2.14 1.36 CD3G,HLA-DQB1 Osteoarthritis Pathway 2.06 1.31 IL1R2,LEF1,MMP9 Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis 2.07 1.31 IL1R2,LEF1,NFAT5 Allograft Rejection Signaling 1.92 1.2 HLA-DQB1,HLA-DRB4 IL-4 Signaling 1.93 1.2 HLA-DQB1,NFAT5 Phosphatidylcholine Biosynthesis I 1.87 1.17 CHPT1 Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes 1.88 1.17 CD3G,NFAT5 Cardiac Hypertrophy Signaling (Enhanced) 1.82 1.14 ADRB2,GNA12,IL1R2,NFAT5 Communication between Innate and Adaptive Immune Cells 1.83 1.14 HLA-DRB4,IGHM PD-1, PD-L1 cancer immunotherapy pathway 1.75 1.09 HLA-DQB1,HLA-DRB4 Type I Diabetes Mellitus Signaling 1.71 1.06 CD3G,HLA-DQB1 MSP-RON Signaling In Macrophages Pathway 1.7 1.05 HLA-DQB1,HLA-DRB4 ..
Inhibition:Article Title: Prediction of Liver Transplant Rejection With a Biologically Relevant Gene Expression Signature
Article Snippet: .. Ingenuity Canonical Pathways -log(pvalue) -log(B-H p-value) Molecules LXR/RXR Activation 5.45 3.19 CD36,CLU,IL1R2,LYZ,MMP9 Glucocorticoid Receptor Signaling 4.57 2.8 ADRB2,CD3G,FCGR1A,IL1R2,MMP9,NFAT5,SLPI Role of NFAT in Regulation of the Immune Response 4.6 2.8 CD3G,FCGR1A,GNA12,HLA-DQB1,NFAT5 B Cell Development 4.34 2.69 HLA-DQB1,IGHM,PTPRC CD28 Signaling in T Helper Cells 4.06 2.65 CD3G,HLA-DQB1,NFAT5,PTPRC iCOS-iCOSL Signaling in T Helper Cells 4.21 2.65 CD3G,HLA-DQB1,NFAT5,PTPRC Systemic Lupus Erythematosus Signaling 4.11 2.65 CD3G,FCGR1A,IGHM,NFAT5,PTPRC Atherosclerosis Signaling 3.98 2.63 CD36,CLU,LYZ,MMP9 Dendritic Cell Maturation 3.36 2.06 CD1D,FCGR1A,HLA-DQB1,HLA-DRB4 OX40 Signaling Pathway 3.16 1.9 CD3G,HLA-DQB1,HLA-DRB4 Protein Kinase A Signaling 3 1.79 FLNA,LEF1,NFAT5,PTPN4,PTPRC T Cell Receptor Signaling 2.95 1.77 CD3G,NFAT5,PTPRC Th1 Pathway 2.78 1.64 CD3G,HLA-DQB1,HLA-DRB4 Inhibition of Angiogenesis by TSP1 2.71 1.6 CD36,MMP9 Antigen Presentation Pathway 2.59 1.56 HLA-DQB1,HLA-DRB4 Neuroinflammation Signaling Pathway 2.58 1.56 HLA-DQB1,MMP9,NFAT5,SNCA Th2 Pathway 2.64 1.56 CD3G,HLA-DQB1,HLA-DRB4 Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis 2.51 1.51 FCGR1A,IL1R2,LEF1,NFAT5 PKCθ Signaling in T Lymphocytes 2.48 1.5 CD3G,HLA-DQB1,NFAT5 Cdc42 Signaling 2.32 1.47 CD3G,HLA-DQB1,HLA-DRB4 Hematopoiesis from Pluripotent Stem Cells 2.39 1.47 CD3G,IGHM Primary Immunodeficiency Signaling 2.38 1.47 IGHM,PTPRC Systemic Lupus Erythematosus In T Cell Signaling Pathway 2.41 1.47 CD3G,GNA12,HLA-DQB1,HLA-DRB4 T Cell Exhaustion Signaling Pathway 2.33 1.47 HLA-DQB1,HLA-DRB4,NFAT5 Th1 and Th2 Activation Pathway 2.36 1.47 CD3G,HLA-DQB1,HLA-DRB4 B Cell Receptor Signaling 2.26 1.42 IGHM,NFAT5,PTPRC ILK Signaling 2.23 1.42 FLNA,LEF1,MMP9 Oxidized GTP and dGTP Detoxification 2.24 1.42 DDX6 IL-8 Signaling 2.17 1.38 DEFA1 (includes others),GNA12,MMP9 Calcium-induced T Lymphocyte Apoptosis 2.14 1.36 CD3G,HLA-DQB1 Osteoarthritis Pathway 2.06 1.31 IL1R2,LEF1,MMP9 Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis 2.07 1.31 IL1R2,LEF1,NFAT5 Allograft Rejection Signaling 1.92 1.2 HLA-DQB1,HLA-DRB4 IL-4 Signaling 1.93 1.2 HLA-DQB1,NFAT5 Phosphatidylcholine Biosynthesis I 1.87 1.17 CHPT1 Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes 1.88 1.17 CD3G,NFAT5 Cardiac Hypertrophy Signaling (Enhanced) 1.82 1.14 ADRB2,GNA12,IL1R2,NFAT5 Communication between Innate and Adaptive Immune Cells 1.83 1.14 HLA-DRB4,IGHM PD-1, PD-L1 cancer immunotherapy pathway 1.75 1.09 HLA-DQB1,HLA-DRB4 Type I Diabetes Mellitus Signaling 1.71 1.06 CD3G,HLA-DQB1 MSP-RON Signaling In Macrophages Pathway 1.7 1.05 HLA-DQB1,HLA-DRB4 ..
Immunopeptidomics:Article Title: Prediction of Liver Transplant Rejection With a Biologically Relevant Gene Expression Signature
Article Snippet: .. Ingenuity Canonical Pathways -log(pvalue) -log(B-H p-value) Molecules LXR/RXR Activation 5.45 3.19 CD36,CLU,IL1R2,LYZ,MMP9 Glucocorticoid Receptor Signaling 4.57 2.8 ADRB2,CD3G,FCGR1A,IL1R2,MMP9,NFAT5,SLPI Role of NFAT in Regulation of the Immune Response 4.6 2.8 CD3G,FCGR1A,GNA12,HLA-DQB1,NFAT5 B Cell Development 4.34 2.69 HLA-DQB1,IGHM,PTPRC CD28 Signaling in T Helper Cells 4.06 2.65 CD3G,HLA-DQB1,NFAT5,PTPRC iCOS-iCOSL Signaling in T Helper Cells 4.21 2.65 CD3G,HLA-DQB1,NFAT5,PTPRC Systemic Lupus Erythematosus Signaling 4.11 2.65 CD3G,FCGR1A,IGHM,NFAT5,PTPRC Atherosclerosis Signaling 3.98 2.63 CD36,CLU,LYZ,MMP9 Dendritic Cell Maturation 3.36 2.06 CD1D,FCGR1A,HLA-DQB1,HLA-DRB4 OX40 Signaling Pathway 3.16 1.9 CD3G,HLA-DQB1,HLA-DRB4 Protein Kinase A Signaling 3 1.79 FLNA,LEF1,NFAT5,PTPN4,PTPRC T Cell Receptor Signaling 2.95 1.77 CD3G,NFAT5,PTPRC Th1 Pathway 2.78 1.64 CD3G,HLA-DQB1,HLA-DRB4 Inhibition of Angiogenesis by TSP1 2.71 1.6 CD36,MMP9 Antigen Presentation Pathway 2.59 1.56 HLA-DQB1,HLA-DRB4 Neuroinflammation Signaling Pathway 2.58 1.56 HLA-DQB1,MMP9,NFAT5,SNCA Th2 Pathway 2.64 1.56 CD3G,HLA-DQB1,HLA-DRB4 Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis 2.51 1.51 FCGR1A,IL1R2,LEF1,NFAT5 PKCθ Signaling in T Lymphocytes 2.48 1.5 CD3G,HLA-DQB1,NFAT5 Cdc42 Signaling 2.32 1.47 CD3G,HLA-DQB1,HLA-DRB4 Hematopoiesis from Pluripotent Stem Cells 2.39 1.47 CD3G,IGHM Primary Immunodeficiency Signaling 2.38 1.47 IGHM,PTPRC Systemic Lupus Erythematosus In T Cell Signaling Pathway 2.41 1.47 CD3G,GNA12,HLA-DQB1,HLA-DRB4 T Cell Exhaustion Signaling Pathway 2.33 1.47 HLA-DQB1,HLA-DRB4,NFAT5 Th1 and Th2 Activation Pathway 2.36 1.47 CD3G,HLA-DQB1,HLA-DRB4 B Cell Receptor Signaling 2.26 1.42 IGHM,NFAT5,PTPRC ILK Signaling 2.23 1.42 FLNA,LEF1,MMP9 Oxidized GTP and dGTP Detoxification 2.24 1.42 DDX6 IL-8 Signaling 2.17 1.38 DEFA1 (includes others),GNA12,MMP9 Calcium-induced T Lymphocyte Apoptosis 2.14 1.36 CD3G,HLA-DQB1 Osteoarthritis Pathway 2.06 1.31 IL1R2,LEF1,MMP9 Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis 2.07 1.31 IL1R2,LEF1,NFAT5 Allograft Rejection Signaling 1.92 1.2 HLA-DQB1,HLA-DRB4 IL-4 Signaling 1.93 1.2 HLA-DQB1,NFAT5 Phosphatidylcholine Biosynthesis I 1.87 1.17 CHPT1 Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes 1.88 1.17 CD3G,NFAT5 Cardiac Hypertrophy Signaling (Enhanced) 1.82 1.14 ADRB2,GNA12,IL1R2,NFAT5 Communication between Innate and Adaptive Immune Cells 1.83 1.14 HLA-DRB4,IGHM PD-1, PD-L1 cancer immunotherapy pathway 1.75 1.09 HLA-DQB1,HLA-DRB4 Type I Diabetes Mellitus Signaling 1.71 1.06 CD3G,HLA-DQB1 MSP-RON Signaling In Macrophages Pathway 1.7 1.05 HLA-DQB1,HLA-DRB4 ..
Expressing:Article Title: Prediction of Liver Transplant Rejection With a Biologically Relevant Gene Expression Signature
Article Snippet: .. Ingenuity Canonical Pathways -log(pvalue) -log(B-H p-value) Molecules LXR/RXR Activation 5.45 3.19 CD36,CLU,IL1R2,LYZ,MMP9 Glucocorticoid Receptor Signaling 4.57 2.8 ADRB2,CD3G,FCGR1A,IL1R2,MMP9,NFAT5,SLPI Role of NFAT in Regulation of the Immune Response 4.6 2.8 CD3G,FCGR1A,GNA12,HLA-DQB1,NFAT5 B Cell Development 4.34 2.69 HLA-DQB1,IGHM,PTPRC CD28 Signaling in T Helper Cells 4.06 2.65 CD3G,HLA-DQB1,NFAT5,PTPRC iCOS-iCOSL Signaling in T Helper Cells 4.21 2.65 CD3G,HLA-DQB1,NFAT5,PTPRC Systemic Lupus Erythematosus Signaling 4.11 2.65 CD3G,FCGR1A,IGHM,NFAT5,PTPRC Atherosclerosis Signaling 3.98 2.63 CD36,CLU,LYZ,MMP9 Dendritic Cell Maturation 3.36 2.06 CD1D,FCGR1A,HLA-DQB1,HLA-DRB4 OX40 Signaling Pathway 3.16 1.9 CD3G,HLA-DQB1,HLA-DRB4 Protein Kinase A Signaling 3 1.79 FLNA,LEF1,NFAT5,PTPN4,PTPRC T Cell Receptor Signaling 2.95 1.77 CD3G,NFAT5,PTPRC Th1 Pathway 2.78 1.64 CD3G,HLA-DQB1,HLA-DRB4 Inhibition of Angiogenesis by TSP1 2.71 1.6 CD36,MMP9 Antigen Presentation Pathway 2.59 1.56 HLA-DQB1,HLA-DRB4 Neuroinflammation Signaling Pathway 2.58 1.56 HLA-DQB1,MMP9,NFAT5,SNCA Th2 Pathway 2.64 1.56 CD3G,HLA-DQB1,HLA-DRB4 Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis 2.51 1.51 FCGR1A,IL1R2,LEF1,NFAT5 PKCθ Signaling in T Lymphocytes 2.48 1.5 CD3G,HLA-DQB1,NFAT5 Cdc42 Signaling 2.32 1.47 CD3G,HLA-DQB1,HLA-DRB4 Hematopoiesis from Pluripotent Stem Cells 2.39 1.47 CD3G,IGHM Primary Immunodeficiency Signaling 2.38 1.47 IGHM,PTPRC Systemic Lupus Erythematosus In T Cell Signaling Pathway 2.41 1.47 CD3G,GNA12,HLA-DQB1,HLA-DRB4 T Cell Exhaustion Signaling Pathway 2.33 1.47 HLA-DQB1,HLA-DRB4,NFAT5 Th1 and Th2 Activation Pathway 2.36 1.47 CD3G,HLA-DQB1,HLA-DRB4 B Cell Receptor Signaling 2.26 1.42 IGHM,NFAT5,PTPRC ILK Signaling 2.23 1.42 FLNA,LEF1,MMP9 Oxidized GTP and dGTP Detoxification 2.24 1.42 DDX6 IL-8 Signaling 2.17 1.38 DEFA1 (includes others),GNA12,MMP9 Calcium-induced T Lymphocyte Apoptosis 2.14 1.36 CD3G,HLA-DQB1 Osteoarthritis Pathway 2.06 1.31 IL1R2,LEF1,MMP9 Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis 2.07 1.31 IL1R2,LEF1,NFAT5 Allograft Rejection Signaling 1.92 1.2 HLA-DQB1,HLA-DRB4 IL-4 Signaling 1.93 1.2 HLA-DQB1,NFAT5 Phosphatidylcholine Biosynthesis I 1.87 1.17 CHPT1 Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes 1.88 1.17 CD3G,NFAT5 Cardiac Hypertrophy Signaling (Enhanced) 1.82 1.14 ADRB2,GNA12,IL1R2,NFAT5 Communication between Innate and Adaptive Immune Cells 1.83 1.14 HLA-DRB4,IGHM PD-1, PD-L1 cancer immunotherapy pathway 1.75 1.09 HLA-DQB1,HLA-DRB4 Type I Diabetes Mellitus Signaling 1.71 1.06 CD3G,HLA-DQB1 MSP-RON Signaling In Macrophages Pathway 1.7 1.05 HLA-DQB1,HLA-DRB4 ..
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